The Organic Chemistry of Drug Design and Drug Action PDF
By:Richard B. Silverman,Mark W. Holladay
Published on 2014-03-29 by Academic Press
The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. Updates to all chapters, including new examples and references Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry Chapter 3 (Receptors): Drug-receptor interactions, cation-π and halogen bonding; atropisomers; case history of the insomnia drug suvorexant Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates
This Book was ranked at 7 by Google Books for keyword Molecular Chemistry.
Book ID of The Organic Chemistry of Drug Design and Drug Action's Books is yAbUAgAAQBAJ, Book which was written byRichard B. Silverman,Mark W. Holladayhave ETAG "U8CSMkTiIh4"
Book which was published by Academic Press since 2014-03-29 have ISBNs, ISBN 13 Code is 9780123820310 and ISBN 10 Code is 0123820316
Reading Mode in Text Status is true and Reading Mode in Image Status is true
Book which have "536 Pages" is Printed at BOOK under CategoryMedical
Book was written in en
eBook Version Availability Status at PDF is true and in ePub is true
Book Preview
Download The Organic Chemistry of Drug Design and Drug Action PDF Free
Download The Organic Chemistry of Drug Design and Drug Action Books Free
Download The Organic Chemistry of Drug Design and Drug Action Free
Download The Organic Chemistry of Drug Design and Drug Action PDF
Download The Organic Chemistry of Drug Design and Drug Action Books
Comments
Post a Comment